Active ingredient
GABA
INCI · Gamma-Aminobutyric Acid
GABA, gamma-aminobutyric acid, is an amino-acid neurotransmitter used topically in cosmetic formulations targeting the appearance of expression lines. Cosmetic claims focus on a transient muscle-relaxation effect at the skin surface; the molecule is a peripheral GABA-receptor ligand. Pairs broadly with most actives. No major conflicts.
Pregnancy and breastfeeding
No specific caution is known for cosmetic use during pregnancy or breastfeeding. If you are unsure, ask your doctor or pharmacist.
Topical cosmetic GABA is considered acceptable during pregnancy and lactation per Mother to Baby. Cosmetic-dose surface application produces negligible systemic exposure.
Mechanism in detail
What GABA does
Amino acid used in expression-line formulas. Contributes to a smoother appearance around dynamic zones.
Evidence
What the research says
- 14 weeksGABA-and-peptide serum: eye lines improved vs baseline
An open-label test in 29 women with photodamaged skin: a serum with GABA and several peptides, used within a full care regimen for 14 weeks, improved eye lines and wrinkles against baseline. No control group.
Read the studyDraelos ZD, Kononov T, Fox T. An Open Label Clinical Trial of a Peptide Treatment Serum and Supporting Regimen Designed to Improve the Appearance of Aging Facial Skin. J Drugs Dermatol. 2016;15(9):1100-1106. PMID: 27602972