Active ingredient
Ceramide
INCICeramide NP
Last reviewed by BIOSAR Scientific Team, PharmD, Cosmetic Chemistry, Pharmacy practice on .
What it is
Ceramides are skin-identical lipids that make up roughly half of the stratum corneum's intercellular matrix, used in skincare to restore a compromised moisture barrier. Topical ceramides — typically NP, AP, and EOP isoforms — supplement the lamellar structure that holds water inside the skin. Pairs broadly with most actives. No major conflicts.
Pregnancy and breastfeeding
Safe
Considered safe during pregnancy and breastfeeding.
Topical ceramides are considered safe during pregnancy and lactation per Mother to Baby and Trivedi et al. (2017). Ceramides are endogenous skin lipids; topical supplementation does not raise systemic exposure concerns.
Mechanism in detail
What Ceramide does
Skin-identical lipid. Rebuilds the barrier between corneocytes and restores comfort to dry, dehydrated skin.
Evidence
What the research says
- −25%Locks moisture in: water loss cut a quarterA cream built on Ceramide NP plus barrier lipids in skin-matching ratio cut transepidermal water loss by about 25% versus baseline within two hours, and held that seal for a full 24 hours. Dry, depleted skin stays hydrated and calm.Read the study →Clin Cosmet Investig Dermatol 2018 (Spada, Barnes, Greive)
Where it helps
Concerns Ceramide addresses
Aging
The first time you notice it is rarely a wrinkle. It is a quality of light — the way your skin catches it differently in a morning mirror,…
Explore the concernDryness
Dryness is a barrier dysfunction in which skin loses water faster than it can retain or replenish it, presenting as flaking, tightness,…
Explore the concernSensitivity
If you have sensitive skin, you have probably been told it is in your head — by a product that says "gentle" on the label, by a friend…
Explore the concernSun Damage
Sun damage is the cumulative photoaging caused by ultraviolet radiation, presenting as solar lentigines, irregular pigmentation, fine…
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