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Active ingredient

Procapil

INCI · Biotinoyl Tripeptide-1 + Apigenin + Oleanolic Acid (delivered in Butylene Glycol and PPG-26-Buteth-26)

Procapil is a tri-active hair-care complex of biotinoyl tripeptide-1, apigenin, and oleanolic acid used in scalp care to support follicle anchoring and reduce hair shedding. It targets the dermal papilla, modulates 5-alpha-reductase activity, and improves microcirculation around the follicle. Pairs well with caffeine and copper-peptide scalp formulas. No major conflicts.

Last reviewed by BIOSAR Scientific Team, PharmD, Cosmetic Chemistry, Pharmacy practice on .

Pregnancy and breastfeeding

No specific caution is known for cosmetic use during pregnancy or breastfeeding. If you are unsure, ask your doctor or pharmacist.

Procapil is a cosmetic-grade peptide-flavonoid complex with negligible systemic absorption from topical scalp use. Mother to Baby flags no concern for cosmetic peptide complexes during pregnancy or lactation.

Mechanism in detail

What Procapil does

Peptide-based complex for the hair follicle cycle. Supports the appearance of fuller, stronger-looking hair over a three-to-four-month course, in line with the natural hair-growth cycle.

Evidence

What the research says

  • 67%Growing-to-resting hair ratio improved in 67% of users

    Placebo-controlled pilot, 35 men with over 20% of hairs in the resting phase: after 4 months, the growing-to-resting ratio improved significantly in 67% of the 18 on Procapil. Maker's data via a 2025 review; placebo result not given.

    Read the study

    Int J Trichology 2025 (Bikash, review)

  • +31.6%Hair growth rate up 31.6% in 60 days, four-active serum

    In 32 healthy adults with hair fall, a daily scalp serum with Procapil and three other actives raised measured hair growth rate by 10.5% at day 30 and 31.6% at day 60; thickness and density rose too. No control group; by the serum's brand.

    Read the study

    J Cosmet Dermatol 2024 (Merja et al.)

Where it helps

Concerns Procapil addresses

  • Hair Loss

    For the months you have been finding more hair on the pillow than the comb. For the part line that has slowly widened. For the new mother, the man at the temple recession, the woman watching her ponytail thin — hair loss is a quiet anxiety that most people carry alone for too long before they ask anyone. The Hairmical range is built around the actives that the dermatology and trichology literature considers most defensible for visible shedding: Procapil's three-mechanism complex, caffeine for follicular microcirculation, biotinyl-tripeptide for follicle anchoring. Topical actives work on the follicle's clock — give them 4 to 8 weeks of consistent use for visible improvement, and months for a full growth cycle.

From the BIOSAR catalog

Products formulated with Procapil

Next ingredientResveratrol