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Active ingredient

Squalane

INCISqualane

Last reviewed by BIOSAR Scientific Team, PharmD, Cosmetic Chemistry, Pharmacy practice on .

What it is

Squalane is the saturated, shelf-stable form of squalene, a lipid the skin produces naturally. It restores the lipid layer of the stratum corneum, supports barrier resilience, and softens the skin without occlusive heaviness. Pairs freely with all other actives. Non-comedogenic. No conflicts.

Pregnancy and breastfeeding
Safe

Considered safe during pregnancy and breastfeeding.

Squalane is a hydrogenated form of an endogenous skin lipid. Mother to Baby flags no concern for cosmetic squalane use during pregnancy or lactation.

Mechanism in detail

What Squalane does

Skin-mimicking lipid derived from plant sources. Delivers barrier support and a non-greasy finish. Pairs well with Retinol to improve tolerability.

Evidence

What the research says

  • 14 daysA moisturiser base with squalane in adults with eczemaA double-blind trial in 32 adults with mild-to-moderate atopic dermatitis compared two moisturisers on the same base, which contained squalane. Hydration rose about 38% with the base alone and 84% with added soothing actives.A clinical study in patients, in a medical setting. It is shown for the science of the ingredient, not as an example of cosmetic use.Read the study →Dermatology Research and Practice 2024